Molar pregnancy

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aka Hydatidiform mole

Abnormal proliferation of pregnancy-associated trophoblastic tissue with malignant potential, can be complete or partial. Very high b-hcg.

Complete - Generalized swelling of villous tissue, diffuse trophoblastic hyperplasia; no embryonic or fetal tissue

Partial - Combination of a fetus with localized placental molar degeneration In 90% of cases, triploid; two sets of chromosomes from father and one from mother

US Appearance

  • Bunch of grapes (multiple sonolucent vesicles 1-30 mm in diameter)
  • Snowstorm appearance (multiple interfaces from tiny cysts)
  • Note invasion of myometrium in invasive choriocarcinoma