Klippel trenaunay weber
- Port-wine stain
- Varicose veins
- Bony and soft tissue extremity hypertrophy
Arteriovenous fistulas, the feature that distinguishes Klippel-Trenaunay syndrome from Parkes-Weber syndrome, are rarely found in the affected extremity.
Possible causes include:
- Intrauterine damage to the sympathetic ganglia or intermediolateral tract leading to dilated microscopic arteriovenous anastomoses.
- Deep vein abnormalities, with resultant obstruction of venous flow, lead to venous hypertension, the development of varices, and limb hypertrophy.
- Underlying mixed mesodermal and ectodermal dysplasia.