Hallervorden Spatz

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  • Rare famillial neurodegenerative disorder
  • Hypointense T2 signal in the globus pallidus with surrounding hyperintense signal giving the eye of the tiger appearance
  • Due to iron accumulation

The Eye-of-the-Tiger Sign


  • Carbon Monoxide - bilateral globus pallidus T2 hyperintensity, hypodense on CT, restricted diffusion
  • Wilson's disease - variable signal in basal ganglia due to copper accumulation, classically putamen, giant panda face
  • Methanol - bilateral putamen necrosis with high T2 signal
  • CJD - high T2 signal in caudate and putamen
  • Leigh's disease