Cystic bone lesions
From Radipedia

Lesion by Location[1]
Differential Diagnosis
Fog Machines or Fegnomashic
- Fibrous dysplasia
- Osteoblastoma
- Giant cell tumor
- Metastatic disease and Myeloma
- Aneurysmal bone cyst
- Chondroblastoma, Chondromyxoid fibroma
- Hyperparathyroidism
- Infection
- Nonossifying fibroma
- Enchondroma, Eosinophilic granuloma
- Solitary bone cyst
Lesions in Patients Younger Than 30 Years Old
- Chondroblastoma
- Aneurysmal bone cyst
- Nonossifying fibroma
- Eosinophilic granuloma
- Solitary bone cyst
- Infection
Epiphyseal Lytic Lesion in Patients Younger Than 30 Years Old
- Chondroblastoma
- Giant cell tumor
- Infection
- Geode or Subchondral cyst
Cystic Rib Lesion - FAME
- Fibrous dysplasia
- Aneurysmal bone cyst
- Myeloma or Metastatic disease
- Enchondroma or Eosinophilic granuloma
Epiphyseal Lesion - CAGGIE
- Chondroblastoma (<25 yo, Ca++ <50%), Clear Cell Chondrosarcoma (>25 yo, rare, +/- Ca++), Chondromyxoid fibroma (metaphyseal, rare, Ca++ rare)
- Arthritis, Aneurysmal bone cyst (from metaphysis, expansile)
- Giant cell tumor (from metaphysis, no matrix, no sclerotic borders, 25-50 yo)
- Ganglion cyst (young adults, no DJD, no matrix)
- Infection (younger patients)
- Eosinophilic granuloma (young, rare in epiphysis)
Also consider these locations as Epiphyseal Equivalents: lesser tuberosity, patella, most apophyses
Four Horsemen of the Apophysis - Chondroblastoma, ABC, GCT, Infection
Fluid Fluid Levels in Lytic Lesion - GOAT
References
- ↑ Madewell JE, Ragsdale BD, Sweet DE. Radiologic and pathologic analysis of solitary bone lesions. Part I: Internal margins. Radiol Clin N Am 1981;19:715-748.