Bronchogenic carcinoma

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1
  • Leading cause of cancer death
  • Non-surgical disease at IIIB and worse, i.e. T4 or N3 makes case non-surgical


Adenocarcinioma (50%)


Squamous Cell Carcinoma (30%)

  • Central location
  • Cavitation can occur
  • Strong smoking association
  • Fast growing
  • In young non-smokers, may be related to HPV and papillomatosis


Small Cell (15%)

  • Central perihilar mass
  • Paraneoplastic syndrome
  • SVC syndrome
  • Grows fast, spreads early


Large Cell (5%)

  • Large, peripheral



Also

  • Bronchial carcinoid makes up 90% of lung low grade malignancy
  • Pulmonary lymphoma - often in immunocompromised