Alveolar proteinosis

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  • Rare disorder in which lipoproteinaceous material accumulates in alveoli due to altered surfactant homeostasis
  • Male preponderance
  • Associated with smoking

Chest radiographic findings are often inconclusive. HRCT demponstrates a combination of ground-glass and interlobular opacities, often in a crazy-paving pattern with geographic involvement.

Differential for Crazy Paving - ground glass opacities and septal thickening